Aim: This study aimed to analyze extramammary Paget's disease (EMPD)-specific survival, overall survival, and recurrence rate (RR) in patients with EMPD in South Korea, with a focus on wide local excision.

Methods: We retrospectively reviewed the medical records of patients with EMPD from 1993 to 2020 at Kyungpook National University Hospital. We determined the survival and RRs after wide local excision.

Results: A total of 95 patients (66 males and 29 females; mean age 67.4 years) were included. The 5-year disease-specific survival and overall survival were 91.8% and 79.3%, respectively, whereas the 10-year rates were 81.6% and 64.7%, respectively. No significant sex differences were observed. Seventy-five patients (78.9%) underwent wide local excision. Mucosal involvement and lymphadenopathy were identified as the significant prognostic factors of disease-specific survival in multivariate analysis. The RR was 14.7% in patients who underwent wide local excision: seven local, two regional, and two distant metastases, with a mean recurrence-free interval of 42.3 months.

Conclusion: Based on the survival and RRs obtained, surgical treatment of EMPD with wide local excision provides fair curative resection.

Practitioner points: Wide local excision can be a feasible treatment option for extramammary Paget's disease.

Authors: Dae-Lyong Ha, Gi Ung Ha, Jun Young Kim, Man-Hoon Han, Hyun Jung Lee, Dae Gy Hong, Jeong Eun Lee, Ho Yun Chung, Seok-Jong Lee